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Creatine and Caffeine: Should You Mix Them?

June 13, 2024 . By Bea Llagas

It’s not uncommon for fitness enthusiasts, athletes, and casual gym-goers to rely on creatine or caffeine to get that extra push in their workouts. These two compounds are some of the most popular ergogenic aids in the fitness industry, meaning they aim to improve performance, endurance, and recovery.

Creatine is renowned for its ability to improve strength and power output, while caffeine is cherished for its stimulatory effects, increasing alertness and reducing fatigue. However, there’s an ongoing debate about whether combining these two is beneficial or if it may diminish their respective effects.

The Difference Between Creatine and Caffeine

Creatine is a naturally occurring compound found in muscle cells and is known for its role in energy production during high-intensity exercise. It’s a go-to supplement for those looking to enhance strength, power, and muscle gains. Conversely, caffeine is the world’s favorite stimulant, revered for its ability to boost energy, focus, and performance. While both can supercharge your workouts, they operate in vastly different ways.

What Do the Experts Say?

Well, the research is mixed. Some studies suggest that caffeine may interfere with the absorption of creatine, potentially lowering its effectiveness. However, others argue that the combination could enhance performance by providing a double dose of energy-boosting benefits.


A 2017 study conducted by The Journal of Strength and Conditioning Research showed no significant differences in power and sprinting performance among those who took creatine mixed with coffee. It’s a scientific tug-of-war, which means more research is needed, but their benefits in athletic performance are widely accepted.

The Pros and Cons

On the plus side, combining creatine and caffeine could potentially amplify your workout performance, leading to greater gains in strength and muscle mass. Plus, the energy boost from caffeine can help power you through those grueling gym sessions. However, there’s also the risk of reduced creatine absorption, which could dampen its benefits. Additionally, some individuals may be more sensitive to the effects of caffeine, experiencing jitters or sleep disturbances.

Best Practices When Mixing Creatine and Caffeine

So, how can you navigate this supplement conundrum? Here are some practical recommendations to consider:

  1. Start with small doses: Begin with low doses of both creatine and caffeine to assess individual tolerance and response. Some experts recommend taking creatine post-workout, while others suggest splitting your doses throughout the day.
  2. Experiment with timing: Everyone’s body reacts differently, so don’t be afraid to experiment with timing to find what works best for you. Whether you prefer to take your caffeine hit before, during, or after your workout, listen to your body and adjust accordingly.
  3. Stay hydrated: Both creatine and caffeine can be dehydrating, so be sure to drink plenty of water throughout the day to keep your body functioning at its best.
  4. Start slow: If you’re new to combining creatine and caffeine, start with smaller doses to gauge your body's response. Gradually increase your intake as needed, paying close attention to how you feel.
  5. Listen to your body: This part is crucial. If you're experiencing any negative side effects or discomfort, it may be a sign that this combination isn't right for you. Always prioritize your health and well-being.

The evidence suggests that combining creatine and caffeine is not inherently detrimental and may even offer synergistic benefits for some individuals. However, individual variability in response should be taken into account, and caution should be exercised, especially when starting a new supplementation regimen. Ultimately, consulting with a healthcare professional or sports nutritionist can provide personalized guidance based on individual needs and goals.

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